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FOXO4 FOXO4-DRI is a D-retro-inverso peptide designed to disrupt the interaction between FOXO4 and p53 transcription factors

Together, they create amplified, sustained growth hormone optimization that mimics more youthful hormonal patterns

Ubiquitin-based probes prepared by total synthesis to profile the activity of deubiquitinating enzymes

In addition, GLP-1RAs exert neuroprotective effects by restoring brain energy metabolism, enhancing BBB integrity, and reducing neurovascular inflammation, oxidative stress, and apoptosis

523 Analysis of gene expression in cortical astrocytes from old mice identified an increase in genes linked to an immune response with a decrease in expression of GFAP and genes related to neuroprotection and neuronal support, 524 and the prominent up-regulation of genes contributing to synapse elimination in astrocytes from aged hippocampus and cerebellum